Philip Janiak Selected Research

7- fluoro- 2- oxo- 4- (2- (4- (thieno(3,2- c)pyridin- 4- yl)piperazin- 1- yl)ethyl)- 1,2- dihydroquinoline- 1- acetamide

8/2004	Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists.
8/2003	SL65.0472 blocks 5-hydroxytryptamine-induced vasoconstriction in a dog hindlimb ischemia model.
11/2002	Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat.

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Philip Janiak Research Topics

Disease

5	Ischemia 08/2004 - 11/2002
4	Heart Failure 01/2021 - 01/2020
3	Inflammation (Inflammations) 01/2021 - 07/2007
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 09/2009
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 07/2007
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2021 - 01/2020
2	Obesity 07/2007 - 11/2002
2	Infarction (Infarctions) 09/2003 - 02/2003
2	Reperfusion Injury 09/2003 - 02/2003
1	Cardiomegaly (Heart Hypertrophy) 01/2022
1	Cardiomyopathies (Cardiomyopathy) 01/2021
1	Atrial Fibrillation 10/2020
1	Lymphopenia (Lymphocytopenia) 10/2020
1	Multiple Sclerosis 10/2020
1	Heart Diseases (Heart Disease) 01/2020
1	Albuminuria 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Systemic Scleroderma (Systemic Sclerosis) 01/2020
1	Chronic Renal Insufficiency 01/2020
1	Stroke (Strokes) 01/2020
1	Respiratory Tract Diseases (Respiratory Tract Disease) 02/2019
1	Cystic Kidney Diseases (Cystic Kidney Disease) 01/2016
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2016
1	Fatty Liver 07/2007
1	Hepatomegaly 07/2007
1	Liver Diseases (Liver Disease) 07/2007
1	Dyslipidemias (Dyslipidemia) 07/2007
1	Diabetic Nephropathies (Diabetic Nephropathy) 03/2006
1	Myocardial Infarction 02/2003
1	Hypersensitivity (Allergy) 11/2002
1	Hyperlipidemias (Hyperlipidemia) 11/2002
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2002

Drug/Important Bio-Agent (IBA)

3	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 10/2020 - 01/2016
3	Serotonin (5 Hydroxytryptamine)IBA 08/2004 - 11/2002
3	7- fluoro- 2- oxo- 4- (2- (4- (thieno(3,2- c)pyridin- 4- yl)piperazin- 1- yl)ethyl)- 1,2- dihydroquinoline- 1- acetamideIBA 08/2004 - 11/2002
3	acetamideIBA 08/2004 - 08/2003
2	Sphingosine-1-Phosphate ReceptorsIBA 01/2022 - 10/2020
2	Peptides (Polypeptides)IBA 01/2021 - 01/2020
2	EnzymesIBA 07/2007 - 05/2002
2	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 08/2004 - 08/2003
1	CollagenIBA 01/2022
1	GTP-Binding Proteins (G-Protein)IBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	ApelinIBA 01/2021
1	Dobutamine FDA LinkGeneric 01/2021
1	ponesimodIBA 10/2020
1	Phosphates (Orthophosphate)IBA 10/2020
1	Phosphotransferases (Kinase)IBA 10/2020
1	siponimodIBA 10/2020
1	Calmodulin (Calcium-Dependent Activator Protein)IBA 10/2020
1	ozanimodIBA 10/2020
1	Lipoprotein(a)IBA 06/2020
1	CreatinineIBA 01/2020
1	SaltsIBA 01/2020
1	Streptozocin (Streptozotocin)FDA Link 01/2020
1	lysophosphatidic acidIBA 01/2020
1	Lysophosphatidic Acid ReceptorsIBA 01/2020
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2020
1	AlbuminsIBA 01/2020
1	urotensin IIIBA 01/2020
1	Actins (F Actin)IBA 01/2020
1	AntibodiesIBA 02/2019
1	rho-Associated KinasesIBA 09/2009
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 07/2007
1	RimonabantIBA 07/2007
1	Alanine Transaminase (SGPT)IBA 07/2007
1	Alkaline PhosphataseIBA 07/2007
1	CholesterolIBA 07/2007
1	Nonesterified Fatty Acids (NEFA)IBA 07/2007
1	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 07/2007
1	Triglycerides (Triacylglycerol)IBA 07/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2007
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 07/2007
1	AdiponectinIBA 07/2007
1	Irbesartan FDA LinkGeneric 03/2006
1	Type 1 Angiotensin ReceptorIBA 03/2006
1	KetanserinIBA 08/2004
1	pyridineIBA 08/2004
1	Serotonin AntagonistsIBA 08/2004
1	SSR180575IBA 09/2003
1	LigandsIBA 09/2003
1	indoleIBA 09/2003
1	GABA-A Receptors (GABA(A) Receptor)IBA 09/2003
1	Vasoconstrictor AgentsIBA 08/2003
1	Sumatriptan (Imigran)FDA LinkGeneric 08/2003
1	Pancreatic Elastase (Elastase)IBA 02/2003
1	Leukocyte Elastase (Neutrophil Elastase)IBA 02/2003
1	SSR 69071IBA 02/2003
1	Serotonin ReceptorsIBA 11/2002
1	Niacinamide (Nicotinamide)FDA LinkGeneric 05/2002

Therapy/Procedure

1	Therapeutics 01/2021
1	Intravenous Administration 01/2021
1	Microspheres (Microsphere) 11/2002